Cesena - Sampdoria

Cristian Shpendi remains the focal point for Cesena as they look to recover from a difficult start to their competitive season. The forward is expected to lead the line in a side that faces significant defensive reshuffling, with Matteo Piacentini sidelined through injury and Massimiliano Mangraviti serving a suspension. After a heavy 3-0 defeat against Sassuolo in the Coppa Italia on 17 August 2026, the home side will be eager to establish a more stable rhythm at Orogel Stadium-Dino Manuzzi on 23 August 2026.

Sampdoria arrive with similar ambitions following their own 2-0 cup exit at the hands of Cremonese. Lorenzo Insigne provides the creative spark for the visitors, who have enjoyed a mixed recent history against their hosts, including a 2-1 victory for Cesena in September 2025 and a goalless draw in April 2026. This matchday 1 encounter offers both teams an immediate opportunity to find their footing in the league.