Leyton Orient - Sheffield Wednesday

Leyton Orient begin their League One campaign at home to Sheffield Wednesday, having started their season with a 2-0 EFL Cup victory over Oxford United on 8 August 2026. Sheffield Wednesday also progressed in the EFL Cup on the same date, overcoming Bolton Wanderers by a single goal.

These two sides met three times in League One during the 2010-11 season, with Sheffield Wednesday winning 1-0 on 9 October 2010 and Leyton Orient responding with a 4-0 victory on 22 January 2011. Their most recent encounter in the competition was on 24 March 2012, when Sheffield Wednesday secured a 1-0 away win.