Oxford - Milton Keynes Dons

The new League One campaign begins with Oxford United hosting Milton Keynes Dons at Kassam Stadium on 15 August 2026. Oxford United enter the season having suffered a 2-0 defeat away to Leyton Orient in the EFL Cup on 8 August. Milton Keynes Dons also faced cup action on the same day, losing 4-1 at Norwich City.

These two sides met most recently in the FA Cup on 9 January, where they drew 1-1. Their league encounters have been closely contested, with Oxford United securing a 1-0 home win on 19 April 2022 and Milton Keynes Dons winning 2-1 at home on 17 September 2022. The history between them suggests a tight contest as they look to start their league campaigns positively.